2005-2013 Mercedes-Benz S-Class (W221) and CL-Class (C216)
Location and description of fuses and relay Mercedes-Benz W221 and C216,2.2L (S250 CDI), 3.0L (S300, S320 CDI, S350 CDI), 3.5L (S350, S400 Hybrid), 4.0L (S420 CDI, S450 CDI), 4.7L (S450, CL 500), 5.5L (S500 / S550, CL 500, S600, CL 600, S63 AMG, CL 63 AMG), 6.0L (S65 AMG, CL 65 AMG), 6.2L (S63 AMG, CL 63 AMG) (2005, 2006, 2007, 2008, 2009, 2010, 2011, 2012, 2013)
Fuse and relay box in rear

Opening: Swing down center armrest.
Open cover behind center armrest.
Pull cover 1 forward in direction of arrow.
Closing: Press cover 1 backward and engage

| No. | A | Description |
|---|---|---|
| 115 | 50 | Heated rear window |
| 116 | 10 | M157, M275, M278: Charge air cooler circulation pump M156: Engine coolant circulation pump S 400 Hybrid: Power electronics circulation pump 2 |
| 117 | 15 | Rear cigar lighter |
| 118 | 30 | M272, M273, OM642: Fuel pump (→2008) W221 with OM629, OM642: Fuel pump (2009→) |
| 15 | S 400 Hybrid: Power electronics circulation pump 1 OM642.8 and OM651 (01.06.2011→): Refrigerant compressor with magnetic | |
| 119 | 7.5 | Front central operating unit |
| 120 | - | - |
| 121 | 10 | Audio tuner control unit |
| 122 | 7.5 | COMAND controller unit |
| 123 | 40 | W221: Right front reversible emergency tensioning retractor |
| 124 | 40 | W221: Left front reversible emergency tensioning retractor |
| 125 | 5 | →31.05.2009: Voice control system (VCS) control unit |
| 126 | 25 | Overhead control panel control unit |
| 127 | 30 | Lumbar pump (2009→) Multicontour seat pneumatic pump (Left/right front multicontour seats) Pneumatic pump for dynamic seat control (Left and right dynamic multicontour seat) |
| 128 | 25 | M275 (→2008): Fuel pump control unit M156, M157, M272, M273, M275, M276, M278, OM642 (2009→): Fuel pump control unit |
| 129 | 25 | →2008: Overhead control panel control unit (Power glass tilting/sliding roof) 2009→: UPCI (Universal Portable Cell Phone Interface) control unit |
| 130 | 30 | Electric parking brake controller unit |
| 131 | 7.5 | Rear window antenna amplifier module |
| 133 | 15 | Trailer recognition control unit Reversing camera (01.09.2010→) |
| 134 | 15 | Luggage compartment socket |
| 135 | 7.5 | Park Assist (→2008): Radar sensors control unit (SGR) Front short range radar sensor unit Rear short range radar sensor unit DISTRONIC PLUS →31.08.2010 or Blind Spot Assist or Adaptive cruise control Plus Light: Radar sensors control unit (SGR) (2009→) PARKTRONIC or Exclusive parking assist: PTS control unit |
| 136 | 7.5 | W221 with OM642.8: AdBlue® control unit |
| 137 | 7.5 | Reversing camera (01.09.2010→) |
| 138 | 5 | Navigation processor (2009-31.08.2010) Emergency call system control unit (2009→) Japan: TV/tuner connector (2009→) |
| 139 | 15 | Rear backrest refrigerator box |
| 140 | 15 | Rear cigar lighter with ashtray illumination connector 115 V socket (2009→) |
| 141 | 5 | Reversing camera control unit |
| 142 | 7.5 | Parktronic system (PTS) control unit Distronic Plus: Radar sensors control unit (SGR) 01.09.2010→ for DISTRONIC PLUS and Active Blind Spot Assist or Active Lane Keeping Assist: Video and radar sensor system control unit |
| 143 | 25 | Rear seats control unit |
| 144 | 25 | Rear seats control unit |
| 145 | 20 | Trailer recognition control unit (→2008) Trailer hitch socket (13-pin) (2009→) |
| 146 | 25 | Trailer recognition control unit |
| 147 | 30 | →2008: TLC [HDS] control unit (Remote trunk closing) |
| 148 | 7.5 | →2008: Universal Portable CTEL Interface (UPCI [UHI]) control unit |
| 25 | 2009→: Panoramic sliding sunroof circuit 30 connector sleeve | |
| 149 | 5 | →2008: Voice control system (VCS [SBS]) control unit |
| 25 | 2009→: Panoramic sliding sunroof control module | |
| 150 | 7.5 | TV combination tuner (analog/digital) Japan: TV/tuner connector (2009→) |
| 151 | 25 | W221; →2008: Electric parking brake controller unit |
| 20 | W221; 2009→: Trailer recognition control unit | |
| 152 | 7.5 | W221: Rear window antenna amplifier module |
| 25 | 115 V socket: DC/AC converter control unit | |
| Relay | ||
| M | Terminal 15 | |
| N | Terminal 15R | |
| O | Power outlet | |
| P | Heated rear window | |
| Q | M156, M157, M275, M278, OM629: Circulation pump S 400 Hybrid: W221.095/195: Power electronics circulation pump 2 | |
| R | Cigar lighter | |
| S | Fuel pump OM642.8 and engine OM651 (01.06.2011→): Connected through the fuel pump: Refrigerant compressor magnetic clutch S 400 Hybrid: Power electronics circulation pump relay 1 | |
Gasoline:
- 3.0L - M272 (S300)
- 3.5L - M272 (S350, S350 BlueEFFICIENCY, S400 Hybrid)
- 4.7L - M273 (S450)
- 5.5L - M273 (S500 / S550)
- 5.5L - M157 (S63 AMG)
- 5.5L - M275 (S600)
- 6.0L - M275 (S65 AMG)
- 6.2L - M156 (S63 AMG)
Diesel:
- 2.2L - OM651 (S250 CDI BlueEFFICIENCY)
- 3.0L - OM642 (S320 CDI, S320 CDI BlueEFFICIENCY, S350 CDI BlueEFFICIENCY, S350 BlueTEC)
- 4.0L - OM629 (S420 CDI, S450 CDI)
CL-Class (C216)
- 4.7L - M276 (CL 500)
- 5.5L - M273 (CL 500)
- 5.5L - M157 (CL 63 AMG)
- 5.5L - M275 (CL 600)
- 6.0L - M275 (CL 65 AMG)
- 6.2L - M156 (CL 63 AMG)
Fuse box in the engine compartment

| No. | A | Description |
|---|---|---|
| 20 | 10 | OM629, OM642, OM651: CDI control unit M156, M157, M272, M273, M275, M276, M278: ME-SFI [ME] control unit |
| 21 | 20 | M156, M157, M272, M273, M275, M276, M278: Terminal 87 M1 i connector sleeve W221 with OM629 and engine OM642: CDI control unit Fuel pump relay W221 with OM651: Quantity control valve |
| 22 | 15 | M156, M157, M272, M273, M276, M278: Terminal 87 connector sleeve |
| 23 | 20 | →2008: Terminal 87 connector sleeve M275 (C216): Terminal 87 M1 i connector sleeve M273 (C216): Terminal 87 M2e connector sleeve M272, M273 (W221): Terminal 87M2i connector sleeve OM642: Terminal 87 connector sleeve 2009→: M156, M157, M272, M273, M275, M276, M278: Terminal 87 connector sleeve W221 with OM629 and engine OM642: Terminal 87 connector sleeve M156, M157, M272, M273, M276, M278: Terminal 87M2e connector sleeve M275: Terminal 87 M2i connector sleeve W221 with OM629 and engine OM642: Terminal 87 connector sleeve W221 with OM651: Rear SAM control unit with fuse and relay module |
| 24 | 25 | M157, M272, M273, M276, M278: Terminal 87M1e connector sleeve OM642: CDI control unit |
| 25 | 7.5 | Instrument cluster |
| 26 | 10 | Left front lamp unit |
| 27 | 10 | Right front lamp unit |
| 28 | 7.5 | M275: EGS control unit except M275: Fully integrated transmission control (VGS) control unit |
| 29 | 5 | Rear SAM control unit with fuse and relay module |
| 30 | 7.5 | OM629, OM642, OM651: CDI control unit M156, M157, M272, M273, M275, M276, M278: ME-SFI [ME] control unit Fuel pump control unit |
| 31 | 5 | S 400 Hybrid: Electric refrigerant compressor |
| 32 | 15 | ECO start/stop function: Transmission oil auxiliary pump control unit S 400 Hybrid: Transmission oil auxiliary pump control unit |
| 33 | 5 | 01.09.2010→ (except S 400 Hybrid): ESP control unit S 400 Hybrid: Battery management system control unit DC/DC converter control unit Power electronics control unit |
| 34 | 5 | S 400 Hybrid: Regenerative braking system control unit |
| 35 | 5 | Electric parking brake controller unit |
| 36 | 10 | Data link connector (Pin 16) |
| 37 | 7.5 | For EIS control unit |
| 38 | 7.5 | Central gateway control unit |
| 39 | 7.5 | Instrument cluster |
| 40 | 7.5 | Upper control panel control unit |
| 41 | 30 | Slave wiper motor |
| 42 | 30 | Master wiper motor |
| 43 | 15 | Front cigar lighter with ashtray illumination |
| 44 | - | - |
| 45 | 5 | S 400 Hybrid: Power electronics circulation pump 1 |
| 46 | 15 | W221 with Active Body Control (ABC), C216: ABC control unit W221 without Active Body Contro (ABC): AIRmatic with ADS control unit |
| 47 | 15 | Front SAM control unit with fuse and relay module Steering column up/down motor |
| 48 | 15 | →2008: Front SAM control unit with fuse and relay module 2009→: Steering column in/out motor |
| 49 | 10 | Steering column module |
| 50 | 15 | AAC [KLA] control unit |
| 51 | 7.5 | →2008: COMAND display |
| 5 | 2009→: COMAND display SPLITVIEW display | |
| 52A | 15 | W221: Left fanfare horn Right fanfare horn |
| 52B | 15 | W221, C216: Left fanfare horn Right fanfare horn |
| 53 | - | - |
| 54 | 40 | AC air recirculation unit |
| 55 | 60 | Gasoline: Electric air pump |
| 56 | 40 | W221 without Active Body Contro (ABC): AIRmatic compressor unit |
| 57 | 40 | →2008: Wiper park position heater |
| 30 | 2009→: Wiper park position heater | |
| 60 | 5 | 2009→: Electrohydraulic power steering |
| 61 | 7.5 | C216; W221 (2009→): Restraint systems control unit |
| 10 | W221 (→2008): Restraint systems control unit | |
| 62 | 5 | Night View Assist control unit |
| 63 | 15 | W221 with OM629 OM642 (01.09.2008→): Fuel filter condensation sensor with heating element |
| 64 | 7.5 | W221 (01.09.2006→): Driver NECK-PRO head restraint solenoid Front passenger NECK-PRO head restraint solenoid |
| 10 | W221 (2009→): Driver NECK-PRO head restraint solenoid Front passenger NECK-PRO head restraint solenoid | |
| 65 | 15 | 01.06.2009→: 12 Volt connector in glove box |
| 66 | 7.5 | DTR controller unit (Distronic or Distronic Plus) |
| Relay | ||
| A | Air pump | |
| B | Air suspension compressor | |
| C | Terminal 87 (engine) | |
| D | Terminal 15 | |
| E | Terminal 87 (chassis) | |
| F | Fanfare horn | |
| G | Terminal 15R | |
| H | Circuit 50, (starter) | |
| J | Circuit 15, (starter) | |
| K | Wiper park heater | |
Left instrument panel fuse box


| No. | A | Description |
|---|---|---|
| 92 | 40 | Left front seat control unit |
| 93 | 7.5 | Restraint systems control unit USA: Weight Sensing System (WSS) control unit |
| 94 | 5 | 2009→: Multifunction camera |
| 95 | - | - |
| 96 | 5 | Tire pressure monitor [RDK] control unit |
| 97 | 7.5 | W221: Audio/video controller control unit (rear entertainment system) |
| 98 | 7.5 | Rear entertainment system: DVD player (2009→) |
| 99 | 7.5 | 2009→: COMAND display SPLITVIEW display |
| 100 | 5 | 2009→: Media interface control unit |
| 101 | 10 | Rear entertainment system: Left rear display Right rear display |
| 102 | 40 | Right front seat control unit |
| 103 | 7.5 | ESP control unit |
| 104 | 40 | Audio tuner control unit |
| 105 | - | - |
| 106 | 1 | Japan: Electronic toll collection (ETC) control unit South Korea (01.09.2010→): TV/tuner connector Valid for navigation (2009→): Navigation processor |
| 107 | 5 | SDAR control unit (SIRIUS satellite radio) (W221 2009→) Digital radio: Digital Audio Broadcasting control unit HD radio: High definition tuner control unit |
| 108 | 5 | W221: Rear air conditioning control unit |
| 109 | 15 | W221: Rear blower intermediate connector |
| 110 | 7.5 | W221: Left rear multicontour backrest control unit Right rear multicontour backrest control unit |
| 111 | 5 | Rear multicontour seat or rear entertainment system (W221): RCP [HBF] control unit |
| 112 | 5 | W221 (→2008): Left front door control unit Right front door control unit S 400 Hybrid: Front SAM control unit with fuse and relay module |
| 113 | 5 | S 400 Hybrid: DC/DC converter control unit |
Right instrument panel fuse box


| No. | A | Description |
|---|---|---|
| 70 | 40 | C216: Right door control unit W221: Right front door control unit |
| 71 | 15 | Keyless Go control unit |
| 72 | 7.5 | S 400 Hybrid: Pyrotechnical separator |
| 73 | 5 | Japan: COMAND controller unit TELE AID emergency call system (2009→): Emergency call system control unit |
| 74 | 30 | TLC [HDS] control unit (Remote trunk closing) |
| 75 | 10 | S 400 Hybrid: Battery management system control unit Power electronics control unit |
| 76 | 15 | S 400 Hybrid: Vacuum pump relay (+) |
| - | W221 with OM642.8: AdBlue® relay supply | |
| 77 | 50 | Advanced sound system: Sound amplifier (2009→) |
| 78 | 25 | S 65 AMG with M275: Additional fan relay (2009→) W221 with OM642.8: AdBlue® relay supply (2009→) |
| 15 | S 400 Hybrid, CL 63 AMG with M157, M278: Charge air cooler circulation pump (2009→) | |
| 79 | 7.5 | Alarm signal horn with additional battery |
| 80 | 40 | C216: Left door control unit W221: Left front door control unit |
| 81 | 30 | C216: Rear control unit |
| 40 | W221: Left rear door control unit | |
| 82 | 30 | C216: Rear control unit |
| 40 | W221: Left rear door control unit | |
| 83 | 30 | Intelligent servo module for DIRECT SELECT |
| 84 | 20 | Advanced sound system: Digital sound processor (2009→) |
| 85 | 10 | AMG: Illuminated door sill moldings (2009→) |
| 86 | - | - |
| 87 | - | - |
| 88 | - | - |
| 89 | - | - |
| 90 | 20 | Stationary heater: STH heater unit (C216) STH or HB heater unit (W221) |
| 91 | 5 | Stationary heater: STH radio remote control receiver S 400 Hybrid: Front SAM control unit with fuse and relay module |
Interior prefuse box (→2008)

| No. | A | Description |
|---|---|---|
| 1 | 400 | Starter |
| 2 | 150 200 | except OM642: Alternator OM642: Alternator |
| 3 | 150 | - |
| 4 | 150 | AAC with integrated control additional fan motor |
| 5 | 200 | OM642: PTC heater booster |
| 6 | 200 | Front SAM control unit with fuse and relay module |
| 7 | 40 | ESP control unit |
| 8 | 25 | ESP control unit |
| 9 | 20 | Front SAM control unit with fuse and relay module |
| 10 | 7.5 | Vehicle power supply control unit |
Interior prefuse box (2009→)

| No. | A | Description |
|---|---|---|
| 3 | 150 | Rear SAM control unit with fuse and relay module |
| 4 | 150 | ECO start/stop function: ECO start/stop function relay S 400 Hybrid: DC/DC converter control unit Heated windshield: Heated windshield control unit |
| 5 | 125 | W221 (Electrical preinstallation for rental vehicle):Special vehicle multifunction control unit (SVMCU [MSS]) |
| 40 | S 400 Hybrid: Vacuum pump | |
| 6 | 80 | Right dashboard fuse box |
| 7 | 150 | W221 with OM629, OM642, OM651: PTC heater booster W221 (Electrical preinstallation for rental vehicle): Special vehicle multifunction control unit (SVMCU [MSS]) |
| 8 | 80 | Front SAM control unit with fuse and relay module |
| 9 | 80 | Left dashboard fuse box |
| 10 | 150 | Rear SAM control unit with fuse and relay module |
Engine compartment prefuse box (→2008)

| No. | A | Description |
|---|---|---|
| 1 | ' | Front prefuse box (via on-board electrical network line pyrofuse |
| 2 | 125 | Heated windshield control unit |
| 3 | 80 | Right instrument panel fuse box |
| 4 | 200 | Rear SAM control unit with fuse and relay module |
| 5 | 100 | Special vehicle multifunction control unit (SVMCU [MSS]) |
| 6 | 150 | Rear SAM control unit with fuse and relay module |
| 7 | 100 | Front SAM control unit with fuse and relay module |
| 8 | 80 | Left instrument panel fuse box |
| 9 | 5 | Front SAM control unit with fuse and relay module |
| 10 | 5 | C216: Emergency call system control unit |
Engine compartment prefuse box (2009→)

| No. | A | Description |
|---|---|---|
| 2 | 400 | Alternator |
| 3 | 150 | Electrohydraulic power steering W221 with OM629, OM642: Glow time output stage |
| 4 | - | Interior prefuse box ( unfused) |
| 5 | 100 | AAC with integrated control additional fan motor |
| 6 | 150 | Front SAM control unit with fuse and relay module |
| 7 | 40 | ESP control unit S 400 Hybrid: Regenerative braking system control unit |
| 8 | 25 | ESP control unit S 400 Hybrid: Regenerative braking system control unit |
| 9 | 25 | Front SAM control unit with fuse and relay module |
| 10 | - | - |
AdBlue fuse block

| No. | A | Description |
|---|---|---|
| A | 7.5 | AdBlue® control unit |
| B | 20 | Heater circuit 1 |
| C | 20 | Heater circuit 2 |
| D | - | - |





